what are the side effects of donating plasma

What Are the Side Effects of Donating Plasma?

Plasma donation is the process of giving blood plasma to a blood bank or plasma center. Plasma is a blood component that helps the body fight off infections and helps to regulate many body functions. Plasma donation is safe and has been done in the United States for over 50 years. Despite its safety, there are some potential side effects that donors should be aware of.

Common Side Effects

The most common side effect of donating plasma is feeling lightheaded or dizzy. This is due to the body’s response to the reduced volume of blood in the body. The body will compensate by releasing hormones that constrict the blood vessels, which can lead to feelings of lightheadedness. Other common side effects include dehydration, fatigue, and nausea. Most of these symptoms will subside after a few minutes.

Rare Side Effects

Rare side effects are those that occur in less than 1% of plasma donors. These side effects include infection, anemia, low blood pressure, and allergic reactions. Infection is a possible side effect of any blood donation, but it is rare. Anemia is a condition in which the body does not make enough red blood cells. Low blood pressure is caused by the body’s reaction to the decrease in volume of blood. Allergic reactions can occur due to the antigens in the plasma.


Q: Is donating plasma safe?

A: Yes, donating plasma is safe. It has been done in the United States for over 50 years with few risks or side effects.

Q: How often can I donate plasma?

A: You can donate plasma every 28 days, up to two times per week.

Q: Can I donate plasma if I have a cold or flu?

A: No, if you are feeling unwell or have any signs of infection, you should not donate plasma.

Q: What if I experience side effects after donating?

A: If you experience any side effects after donating plasma, such as dizziness, nausea, or fatigue, you should contact your doctor.


Donating plasma is a safe and effective way to help others while also earning some extra money. While there are some potential side effects, most of them are mild and short-lived. However, if you experience any severe or long-lasting side effects, you should contact your doctor. Before donating plasma, make sure you are healthy and hydrated and always follow the instructions of the staff at the donation center.


1. https://www.redcrossblood.org/donating-blood/types-of-blood-donations/plasma-donation.html

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248234/